Nature Communications (Oct 2021)
Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition
- Laura C. D. Pomatto-Watson,
- Monica Bodogai,
- Oye Bosompra,
- Jonathan Kato,
- Sarah Wong,
- Melissa Carpenter,
- Eleonora Duregon,
- Dolly Chowdhury,
- Priya Krishna,
- Sandy Ng,
- Emeline Ragonnaud,
- Roberto Salgado,
- Paula Gonzalez Ericsson,
- Alberto Diaz-Ruiz,
- Michel Bernier,
- Nathan L. Price,
- Arya Biragyn,
- Valter D. Longo,
- Rafael de Cabo
Affiliations
- Laura C. D. Pomatto-Watson
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Monica Bodogai
- Immunoregulation Section (IS), Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health
- Oye Bosompra
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Jonathan Kato
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Sarah Wong
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Melissa Carpenter
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Eleonora Duregon
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Dolly Chowdhury
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Priya Krishna
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Sandy Ng
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Emeline Ragonnaud
- Immunoregulation Section (IS), Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health
- Roberto Salgado
- Department of Pathology, GZA-ZNA Hospitals
- Paula Gonzalez Ericsson
- Breast Cancer Research Program, Vanderbilt University Medical Center
- Alberto Diaz-Ruiz
- Nutritional Interventions Group, Precision Nutrition and Aging Institute, IMDEA Food
- Michel Bernier
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Nathan L. Price
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Arya Biragyn
- Immunoregulation Section (IS), Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health
- Valter D. Longo
- Longevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California
- Rafael de Cabo
- Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-26431-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Caloric restriction (CR) has been shown as an effective intervention to reduce tumorigenesis, but alternative less stringent dietary interventions have also been considered. Here, the authors show that in a murine model of breast cancer CR has a larger effect on preventing tumorigenesis and metastasis compared to periodic caloric cycling.
