Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation

Novickij V.; Grainys A.; Novickij J.

doi:10.2478/msr-2013-0024

Measurement Science Review (Jun 2013)

Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation

Novickij V.,
Grainys A.,
Novickij J.

Affiliations

Novickij V.: Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko street 41, Vilnius LT-03327, Lithuania
Grainys A.: Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko street 41, Vilnius LT-03327, Lithuania
Novickij J.: Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko street 41, Vilnius LT-03327, Lithuania

DOI: https://doi.org/10.2478/msr-2013-0024
Journal volume & issue: Vol. 13, no. 3
pp. 152 – 156

Abstract

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The microfluidic channel with a planar inductive microcoil for the cell membrane permeabilization and the integrated planar electrodes for cell dielectrophoretic manipulation is proposed and analyzed in the study. The analyzed setup is based on the dielectrophoretic entrapment of the biological cell followed by membrane permeabilization using high pulsed magnetic field. The finite element method analysis of the DEP force and the generated pulsed magnetic field is performed. Based on finite element method analysis the potential applications of the setup in the fields of drug delivery, biomedicine and biotechnology are discussed.

Published in Measurement Science Review

ISSN: 1335-8871 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Science: Mathematics
Website: https://sciendo.com/journal/MSR

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