Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

Gavin Li; Meghan Berkenstock; Uri Soiberman

American Journal of Ophthalmology Case Reports (Sep 2020)

Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

Gavin Li,
Meghan Berkenstock,
Uri Soiberman

Affiliations

Gavin Li: The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe St, Baltimore, MD, 21237, USA
Meghan Berkenstock: The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe St, Baltimore, MD, 21237, USA
Uri Soiberman: Corresponding author. 600 N. Wolfe St. Baltimore, MD 21287, USA.; The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe St, Baltimore, MD, 21237, USA

Journal volume & issue: Vol. 19
p. 100848

Abstract

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Purpose: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. Observations: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab. Conclusion and importance: Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.

Published in American Journal of Ophthalmology Case Reports

ISSN: 2451-9936 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Ophthalmology
Website: http://www.journals.elsevier.com/american-journal-of-ophthalmology-case-reports/

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