Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

N. Pien; Y. Van de Maele; L. Parmentier; M. Meeremans; A. Mignon; C. De Schauwer; I. Peeters; L. De Wilde; A. Martens; D. Mantovani; S. Van Vlierberghe; P. Dubruel

doi:10.1007/s10856-022-06673-4

Journal of Materials Science: Materials in Medicine (May 2022)

Design of an electrospun tubular construct combining a mechanical and biological approach to improve tendon repair

N. Pien,
Y. Van de Maele,
L. Parmentier,
M. Meeremans,
A. Mignon,
C. De Schauwer,
I. Peeters,
L. De Wilde,
A. Martens,
D. Mantovani,
S. Van Vlierberghe,
P. Dubruel

Affiliations

N. Pien: Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent University
Y. Van de Maele: Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent University
L. Parmentier: Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent University
M. Meeremans: Faculty of Veterinary Medicine, Department of Translational Physiology, Infectiology and Public Health, Ghent University
A. Mignon: Smart Polymeric Biomaterials, Surface and Interface Engineered Materials, KU Leuven
C. De Schauwer: Faculty of Veterinary Medicine, Department of Translational Physiology, Infectiology and Public Health, Ghent University
I. Peeters: Faculty of Medicine and Health Sciences, Department of Human Structure and Repair, Ghent University Hospital
L. De Wilde: Faculty of Medicine and Health Sciences, Department of Human Structure and Repair, Ghent University Hospital
A. Martens: Faculty of Veterinary Medicine, Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Ghent University
D. Mantovani: Laboratory for Biomaterials and Bioengineering, Department of Min-Met-Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University
S. Van Vlierberghe: Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent University
P. Dubruel: Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry (CMaC), Ghent University

DOI: https://doi.org/10.1007/s10856-022-06673-4
Journal volume & issue: Vol. 33, no. 6
pp. 1 – 17

Abstract

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Highlights Synthesis of a novel acrylate-endcapped urethane-based precursor (AUP). Physico-chemical characterization of the developed AUP material. Development of a reinforced electrospun tubular repair construct containing bioactive components. Mechanical evaluation of the repair constructs on ex vivo sheep tendons. Biological evaluation of the repair constructs by means of indirect and direct testing using mono- and co-cultures.

Published in Journal of Materials Science: Materials in Medicine

ISSN: 0957-4530 (Print); 1573-4838 (Online)
Publisher: Springer
Country of publisher: Switzerland
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Medicine: Medicine (General): Medical technology
Website: https://www.springer.com/journal/10856

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