Frontiers in Medicine (Apr 2024)

Case report: Methicillin-resistant Staphylococcus aureus with penicillin susceptible (PS-MRSA): first clinical report from a psychiatric hospital in China

  • Fei Yan,
  • Fei Yan,
  • Mi Yang,
  • Mi Yang,
  • Yuting Sun,
  • Yuting Sun,
  • Qin Tang,
  • Qin Tang,
  • Lu Yuan,
  • Lu Yuan

DOI
https://doi.org/10.3389/fmed.2024.1380369
Journal volume & issue
Vol. 11

Abstract

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This case report documents the first instance of Penicillin-Susceptible Methicillin-Resistant Staphylococcus aureus (PS-MRSA) in a Chinese psychiatric hospital. The strain was isolated from a patient with Alzheimer’s disease who had a lower respiratory tract infection. Clinical and laboratory analyses, including mass spectrometry, antibiotic susceptibility testing, and whole-genome sequencing, confirmed the PS-MRSA strain. In this case, we systematically introduce the clinical symptoms, laboratory findings, and treatment responses associated with this PS-MRSA strain. This discovery offers a new perspective on our understanding of resistance mechanisms and expands our considerations for existing antibiotic treatments. It may fill a gap in the classification of MRSA strains, enhance the spectrum of MRSA resistance, and complete the therapeutic strategies for MRSA.

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