Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis
Elisabet Roca-Millan,
Judith Domínguez-Mínger,
Mayra Schemel-Suárez,
Albert Estrugo-Devesa,
Antonio Marí-Roig,
José López-López
Affiliations
Elisabet Roca-Millan
Faculty of Medicine and Health Sciences (School of Dentistry), University of Barcelona, 08907 Barcelona, Spain
Judith Domínguez-Mínger
Faculty of Medicine and Health Sciences (School of Dentistry), University of Barcelona, 08907 Barcelona, Spain
Mayra Schemel-Suárez
Faculty of Medicine and Health Sciences (School of Dentistry), University of Barcelona, 08907 Barcelona, Spain
Albert Estrugo-Devesa
Oral Health and Masticatory System Group-IDIBELL, Faculty of Medicine and Health Sciences (School of Dentistry), Odontological Hospital University of Barcelona, University of Barcelona, 08907 Barcelona, Spain
Antonio Marí-Roig
Department of Maxillofacial Surgery, University Hospital of Bellvitge, 08907 Barcelona, Spain
José López-López
Oral Health and Masticatory System Group-IDIBELL, Faculty of Medicine and Health Sciences (School of Dentistry), Odontological Hospital University of Barcelona, University of Barcelona, 08907 Barcelona, Spain
The exponential growth in the use of dental implants in the last decades has been accompanied by an increase in the prevalence of peri-implant disease. It appears that viruses may have pathogenic potential for the development of this pathology. The objective of this systematic review is to study the possible association between the presence of Epstein–Barr virus and the development of peri-implantitis. An electronic search was conducted in PubMed/MEDLINE, Scielo and Embase databases for cross-sectional and case–control studies in humans published up to and including 4 January 2021. Five studies were included in the qualitative analysis. The meta-analysis did not show a statistically significant difference regarding the prevalence of Epstein–Barr virus in the peri-implant sulcus between implants with peri-implantitis and healthy implants. In conclusion, no association between the human herpesvirus 4 and peri-implantitis was found. Further research on this topic is essential to develop more effective treatments.
