Nature Communications (Jul 2018)
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
- Tomoko Saito,
- Atsushi Niida,
- Ryutaro Uchi,
- Hidenari Hirata,
- Hisateru Komatsu,
- Shotaro Sakimura,
- Shuto Hayashi,
- Sho Nambara,
- Yosuke Kuroda,
- Shuhei Ito,
- Hidetoshi Eguchi,
- Takaaki Masuda,
- Keishi Sugimachi,
- Taro Tobo,
- Haruto Nishida,
- Tsutomu Daa,
- Kenichi Chiba,
- Yuichi Shiraishi,
- Tetsuichi Yoshizato,
- Masaaki Kodama,
- Tadayoshi Okimoto,
- Kazuhiro Mizukami,
- Ryo Ogawa,
- Kazuhisa Okamoto,
- Mitsutaka Shuto,
- Kensuke Fukuda,
- Yusuke Matsui,
- Teppei Shimamura,
- Takanori Hasegawa,
- Yuichiro Doki,
- Satoshi Nagayama,
- Kazutaka Yamada,
- Mamoru Kato,
- Tatsuhiro Shibata,
- Masaki Mori,
- Hiroyuki Aburatani,
- Kazunari Murakami,
- Yutaka Suzuki,
- Seishi Ogawa,
- Satoru Miyano,
- Koshi Mimori
Affiliations
- Tomoko Saito
- Department of Surgery, Kyushu University Beppu Hospital
- Atsushi Niida
- Division of Health Medical Computational Science, Health Intelligence Center, Institute of Medical Science, The University of Tokyo
- Ryutaro Uchi
- Department of Surgery, Kyushu University Beppu Hospital
- Hidenari Hirata
- Department of Surgery, Kyushu University Beppu Hospital
- Hisateru Komatsu
- Department of Surgery, Kyushu University Beppu Hospital
- Shotaro Sakimura
- Department of Surgery, Kyushu University Beppu Hospital
- Shuto Hayashi
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Sho Nambara
- Department of Surgery, Kyushu University Beppu Hospital
- Yosuke Kuroda
- Department of Surgery, Kyushu University Beppu Hospital
- Shuhei Ito
- Department of Surgery, Kyushu University Beppu Hospital
- Hidetoshi Eguchi
- Department of Surgery, Kyushu University Beppu Hospital
- Takaaki Masuda
- Department of Surgery, Kyushu University Beppu Hospital
- Keishi Sugimachi
- Department of Surgery, Kyushu University Beppu Hospital
- Taro Tobo
- Department of Pathology, Kyushu University Beppu Hospital
- Haruto Nishida
- Department of Diagnostic Pathology, Oita University Hospital
- Tsutomu Daa
- Department of Diagnostic Pathology, Oita University Hospital
- Kenichi Chiba
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Yuichi Shiraishi
- Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Tetsuichi Yoshizato
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Masaaki Kodama
- Department of Gastroenterology, Oita University Hospital
- Tadayoshi Okimoto
- Department of Gastroenterology, Oita University Hospital
- Kazuhiro Mizukami
- Department of Gastroenterology, Oita University Hospital
- Ryo Ogawa
- Department of Gastroenterology, Oita University Hospital
- Kazuhisa Okamoto
- Department of Gastroenterology, Oita University Hospital
- Mitsutaka Shuto
- Department of Gastroenterology, Oita University Hospital
- Kensuke Fukuda
- Department of Gastroenterology, Oita University Hospital
- Yusuke Matsui
- Division of Systems Biology, Nagoya University Graduate School of Medicine
- Teppei Shimamura
- Division of Systems Biology, Nagoya University Graduate School of Medicine
- Takanori Hasegawa
- Division of Health Medical Data Science, Health Intelligence Center, Institute of Medical Science, The University of Tokyo
- Yuichiro Doki
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Satoshi Nagayama
- Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research
- Kazutaka Yamada
- Department of Surgery, Takano Hospital
- Mamoru Kato
- Department of Bioinformatics, National Cancer Center Research Institute
- Tatsuhiro Shibata
- Division of Cancer Genomics, National Cancer Center Research Institute
- Masaki Mori
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Hiroyuki Aburatani
- Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
- Kazunari Murakami
- Department of Gastroenterology, Oita University Hospital
- Yutaka Suzuki
- Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Seishi Ogawa
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
- Satoru Miyano
- Division of Health Medical Computational Science, Health Intelligence Center, Institute of Medical Science, The University of Tokyo
- Koshi Mimori
- Department of Surgery, Kyushu University Beppu Hospital
- DOI
- https://doi.org/10.1038/s41467-018-05226-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ.
