Is there any link between vitamin D deficiency and vasovagal syncope?

Journal of Arrhythmia. 2020;36(2):371-376 DOI 10.1002/joa3.12309

 

Journal Homepage

Journal Title: Journal of Arrhythmia

ISSN: 1880-4276 (Print); 1883-2148 (Online)

Publisher: Wiley

Society/Institution: Japanese Heart Rhythm Society

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system

Country of publisher: Australia

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Songül Usalp (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Hatice Kemal (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Ümit Yüksek (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Belma Yaman (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Aziz Günsel (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Oğuzhan Edebal (Department of Clinical Biochemistry Near East University Faculty of Medicine Nicosia Cyprus)

Onur Akpınar (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Levent Cerit (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

Hamza Duygu (Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 45 weeks

 

Abstract | Full Text

Abstract Background This study aimed to investigate serum 25[OH]D levels between patients with vasovagal syncope (VVS) diagnosed with head‐up tilt table test (HUTT) and age‐matched healthy people. Methods The study included 75 consecutive patients (32.3 ± 10.7 years), who presented with syncope and underwent HUTT and 52 healthy controls (32.9 ± 14.1 years). HUTT patients were divided into two groups according to whether there was syncope response to the test. Patients underwent cardiac, psychiatric, and neurological investigation. Serum 25[OH]D levels were measured by chemiluminescent microparticle immunoassay method. Results There was no difference between the two groups in terms of age, gender, body mass index (BMI), echocardiographic findings (P > .05). Mean serum 25[OH]D (24.5 ± 6.3 vs 20.1 ± 8.8 ng/mL, P = .003) and vitamin B12 levels (436.4 ± 199.2 vs 363.1 ± 107.6 pg/mL, P = .009) was lower in syncope patients when compared to the control group. In correlation analyses, syncope was shown as correlated with the vitamin D (r = −264, P = .003) and vitamin B12 levels (r = −233, P = .009). But, multivariate regression analyses showed that only vitamin D increased risk of syncope [OR: 0.946, 95% CI (0.901‐0.994)]. There was no difference in terms of age, gender, BMI, echocardiographic findings between the in HUTT positive (n = 45) and negative groups (n = 29). Only vitamin D level was significantly lower in HUTT positive group (17.5 ± 7.7 vs 24.4 ± 9.1 ng/mL, P = .002). There was no difference among in the vasovagal subgroups in terms of vitamin D level and other features. Conclusion Vitamin D and B12 levels were reasonably low in syncope patients, but especially low Vitamin D levels were associated with VVS diagnosed in HUTT.