Frontiers in Genetics (Jul 2018)
COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents
- Sabina K. Millenet,
- Frauke Nees,
- Frauke Nees,
- Stefan Heintz,
- Christiane Bach,
- Christiane Bach,
- Josef Frank,
- Sabine Vollstädt-Klein,
- Arun Bokde,
- Uli Bromberg,
- Christian Büchel,
- Erin B. Quinlan,
- Sylvane Desrivières,
- Juliane Fröhner,
- Herta Flor,
- Herta Flor,
- Vincent Frouin,
- Hugh Garavan,
- Penny Gowland,
- Andreas Heinz,
- Bernd Ittermann,
- Herve Lemaire,
- Jean-Luc Martinot,
- Marie-Laure P. Martinot,
- Dimitri O. Papadoulos,
- Tomáš Paus,
- Luise Poustka,
- Marcella Rietschel,
- Michael N. Smolka,
- Henrik Walter,
- Rob Whelan,
- Gunter Schumann,
- Tobias Banaschewski,
- Sarah Hohmann
Affiliations
- Sabina K. Millenet
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Frauke Nees
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Frauke Nees
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Stefan Heintz
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Christiane Bach
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Christiane Bach
- Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, Germany
- Josef Frank
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Sabine Vollstädt-Klein
- Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Arun Bokde
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
- Uli Bromberg
- University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Christian Büchel
- University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Erin B. Quinlan
- Centre for Population Neuroscience and Stratified Medicine and MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
- Sylvane Desrivières
- Centre for Population Neuroscience and Stratified Medicine and MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
- Juliane Fröhner
- Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany
- Herta Flor
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Herta Flor
- 0Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany
- Vincent Frouin
- 1NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France
- Hugh Garavan
- 2Department of Psychiatry and Psychology, University of Vermont, Burlington, VT, United States
- Penny Gowland
- 3Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
- Andreas Heinz
- 4Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Bernd Ittermann
- 5Physikalisch-Technische Bundesanstalt, Braunschweig Institute Berlin, Germany
- Herve Lemaire
- 6Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry,” Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre; and Université Paris Descartes, Sorbonne Paris Cité, Paris, France
- Jean-Luc Martinot
- 7Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry,” University Paris Sud – Paris Saclay, University Paris Descartes; Service Hospitalier Frédéric Joliot, Orsay; and Maison de Solenn, Paris, France
- Marie-Laure P. Martinot
- 8Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry,” University Paris Sud – Paris Saclay, University Paris Descartes; and AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France
- Dimitri O. Papadoulos
- 1NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France
- Tomáš Paus
- 9Rotman Research Institute, Baycrest Centre for Geriatric Care, Department of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada
- Luise Poustka
- 0Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany
- Marcella Rietschel
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Michael N. Smolka
- Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany
- Henrik Walter
- 4Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Rob Whelan
- 1Trinity College Dublin, Dublin, Ireland
- Gunter Schumann
- Centre for Population Neuroscience and Stratified Medicine and MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Sarah Hohmann
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- DOI
- https://doi.org/10.3389/fgene.2018.00284
- Journal volume & issue
-
Vol. 9
Abstract
The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16–17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals.
Keywords
