Is it possible to achieve sustained remission or cure of type 2 diabetes mellitus in the 21st century?

Abstract

A practitioner has a wide range of the hypoglycemic drugs for type 2 diabetes mellitus (T2DM) treatment, which can be used within a normal or near-normal range for long-term glycemic control. However, the question remains whether there are ways to achieve not only satisfactory glycemic control, but also T2DM remission (or even complete cure). The review presents an update on the concept of T2DM remission and describes the ways of its possible achievement with non-drug and drug treatments and surgery. The mechanisms of T2DM remission are given.

Keywords

• diabetes mellitus
• diabetes remission
• weight loss
• gastrointestinal hormones
• metabolic surgery