Communications Biology (Sep 2022)
Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics
- Nancy Aguilera,
- Tao Liu,
- Andrew J. Bower,
- Joanne Li,
- Sarah Abouassali,
- Rongwen Lu,
- John Giannini,
- Maximilian Pfau,
- Chelsea Bender,
- Margery G. Smelkinson,
- Amelia Naik,
- Bin Guan,
- Owen Schwartz,
- Andrei Volkov,
- Alfredo Dubra,
- Zhuolin Liu,
- Daniel X. Hammer,
- Dragan Maric,
- Robert Fariss,
- Robert B. Hufnagel,
- Brett G. Jeffrey,
- Brian P. Brooks,
- Wadih M. Zein,
- Laryssa A. Huryn,
- Johnny Tam
Affiliations
- Nancy Aguilera
- National Eye Institute, National Institutes of Health
- Tao Liu
- National Eye Institute, National Institutes of Health
- Andrew J. Bower
- National Eye Institute, National Institutes of Health
- Joanne Li
- National Eye Institute, National Institutes of Health
- Sarah Abouassali
- National Eye Institute, National Institutes of Health
- Rongwen Lu
- National Eye Institute, National Institutes of Health
- John Giannini
- National Eye Institute, National Institutes of Health
- Maximilian Pfau
- National Eye Institute, National Institutes of Health
- Chelsea Bender
- National Eye Institute, National Institutes of Health
- Margery G. Smelkinson
- National Institute of Allergy and Infectious Disease, Research Technologies Branch, National Institutes of Health
- Amelia Naik
- National Eye Institute, National Institutes of Health
- Bin Guan
- National Eye Institute, National Institutes of Health
- Owen Schwartz
- National Institute of Allergy and Infectious Disease, Research Technologies Branch, National Institutes of Health
- Andrei Volkov
- National Eye Institute, National Institutes of Health
- Alfredo Dubra
- Department of Ophthalmology, Stanford University
- Zhuolin Liu
- Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration
- Daniel X. Hammer
- Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration
- Dragan Maric
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Robert Fariss
- National Eye Institute, National Institutes of Health
- Robert B. Hufnagel
- National Eye Institute, National Institutes of Health
- Brett G. Jeffrey
- National Eye Institute, National Institutes of Health
- Brian P. Brooks
- National Eye Institute, National Institutes of Health
- Wadih M. Zein
- National Eye Institute, National Institutes of Health
- Laryssa A. Huryn
- National Eye Institute, National Institutes of Health
- Johnny Tam
- National Eye Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s42003-022-03842-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
The in vivo pathogenesis of the blinding retinal degeneration choroideremia is visualized, which reveals enlarged and area-disrupted retinal pigment epithelial cells, providing evidence for polymegathism in choroideremia.
