The role of antioxidants in high risk pregnancy

Abstract

The article describes the current understanding of the oxidative stress and its influence on the development of pregnancy complications: premature labor, preterm premature rupture of the membranes, preeclampsia, placental insufficiency, intrauterine growth restriction, congenital malformations. Particular attention is paid to the role of antioxidants in prophylaxis of pregnancy disorders and of a number of diseases in neonates. Vitamins and micronutrients supplementation may help restore balance to the oxidative pathways. The development of safe and efficient antioxidant strategies to prevent o minimize oxidative damage before and during pregnancy and during lactation are required.

Keywords

• oxidative stress
• pregnancy
• premature labor
• preeclampsia
• antioxidants
• anti-oxidative therapy