Nature Communications (Mar 2019)
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
- Maddalena Noviello,
- Francesco Manfredi,
- Eliana Ruggiero,
- Tommaso Perini,
- Giacomo Oliveira,
- Filippo Cortesi,
- Pantaleo De Simone,
- Cristina Toffalori,
- Valentina Gambacorta,
- Raffaella Greco,
- Jacopo Peccatori,
- Monica Casucci,
- Giulia Casorati,
- Paolo Dellabona,
- Masahiro Onozawa,
- Takanori Teshima,
- Marieke Griffioen,
- Constantijn J. M. Halkes,
- J. H. F. Falkenburg,
- Friedrich Stölzel,
- Heidi Altmann,
- Martin Bornhäuser,
- Miguel Waterhouse,
- Robert Zeiser,
- Jürgen Finke,
- Nicoletta Cieri,
- Attilio Bondanza,
- Luca Vago,
- Fabio Ciceri,
- Chiara Bonini
Affiliations
- Maddalena Noviello
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- Francesco Manfredi
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- Eliana Ruggiero
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- Tommaso Perini
- IRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit
- Giacomo Oliveira
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- Filippo Cortesi
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Experimental Immunology Unit
- Pantaleo De Simone
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- Cristina Toffalori
- IRCCS San Raffaele Scientifc Institute, Division of Immunology, Transplantation and Infectious Disease, Unit of Immunogenetics, Leukemia Genomics and Immunobiology
- Valentina Gambacorta
- IRCCS San Raffaele Scientifc Institute, Division of Immunology, Transplantation and Infectious Disease, Unit of Immunogenetics, Leukemia Genomics and Immunobiology
- Raffaella Greco
- IRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit
- Jacopo Peccatori
- IRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit
- Monica Casucci
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Innovative Immunotherapies Unit
- Giulia Casorati
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Experimental Immunology Unit
- Paolo Dellabona
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Experimental Immunology Unit
- Masahiro Onozawa
- Hokkaido University Faculty of Medicine, Graduate School of Medicine, Department of Hematology
- Takanori Teshima
- Hokkaido University Faculty of Medicine, Graduate School of Medicine, Department of Hematology
- Marieke Griffioen
- Leiden University Medical Center (LUMC), Department of Hematology
- Constantijn J. M. Halkes
- Leiden University Medical Center (LUMC), Department of Hematology
- J. H. F. Falkenburg
- Leiden University Medical Center (LUMC), Department of Hematology
- Friedrich Stölzel
- Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden
- Heidi Altmann
- Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden
- Martin Bornhäuser
- Department of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Technical University Dresden
- Miguel Waterhouse
- University of Freiburg Medical Center, Department of Hematology, Oncology and Stem Cell Transplantation
- Robert Zeiser
- University of Freiburg Medical Center, Department of Hematology, Oncology and Stem Cell Transplantation
- Jürgen Finke
- University of Freiburg Medical Center, Department of Hematology, Oncology and Stem Cell Transplantation
- Nicoletta Cieri
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- Attilio Bondanza
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Innovative Immunotherapies Unit
- Luca Vago
- IRCCS San Raffaele Scientifc Institute, Division of Immunology, Transplantation and Infectious Disease, Unit of Immunogenetics, Leukemia Genomics and Immunobiology
- Fabio Ciceri
- IRCCS San Raffaele Scientific Institute, Hematology and Hematopoietic Stem Cell Transplantation Unit
- Chiara Bonini
- IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit
- DOI
- https://doi.org/10.1038/s41467-019-08871-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.
