The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications

Abstract

Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, discuss chemical inhibitors of this process, and discuss potential clinical applications of the endocytosis inhibitors.

Keywords

• clathrin-mediated endocytosis
• clathrin-independent endocytosis
• cell-penetrating peptides
• inhibitors of endocytosis