Analysis of local and systemic inflammatory responses induced by polymicrobial peritonitis in mice

Affiliations

Tânia Silvia Fröde: Department of Clinical Analysis, Centre of Healthy Sciences, CCS, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil
Silvia Ines Alejandra Cordoba Pires Ferreira: Laboratory of Santa Luzia, Centre of Biological Sciences, CCS, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil
Yara Santos Medeiros: Department of Pharmacology, Centre of Biological Sciences, CCS, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, Florianópolis 88040–970, SC, Brazil

Abstract

Background: Abdominal sepsis induces a local production of proinflammatory mediators that may trigger both septic shock and organ-system dysfunction.