Nature Communications (Nov 2020)
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer
- Mark Gormley,
- Tom Dudding,
- Eleanor Sanderson,
- Richard M. Martin,
- Steven Thomas,
- Jessica Tyrrell,
- Andrew R. Ness,
- Paul Brennan,
- Marcus Munafò,
- Miranda Pring,
- Stefania Boccia,
- Andrew F. Olshan,
- Brenda Diergaarde,
- Rayjean J. Hung,
- Geoffrey Liu,
- George Davey Smith,
- Rebecca C. Richmond
Affiliations
- Mark Gormley
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Tom Dudding
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Eleanor Sanderson
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Richard M. Martin
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Steven Thomas
- Bristol Dental Hospital and School, University of Bristol
- Jessica Tyrrell
- RD&E Hospital, University of Exeter Medical School
- Andrew R. Ness
- University Hospitals Bristol and Weston NHS Foundation Trust National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol
- Paul Brennan
- Genetic Epidemiology Group, World Health Organization, International Agency for Research on Cancer
- Marcus Munafò
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Miranda Pring
- Bristol Dental Hospital and School, University of Bristol
- Stefania Boccia
- Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore
- Andrew F. Olshan
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Brenda Diergaarde
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, and UPMC Hillman Cancer Center
- Rayjean J. Hung
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Geoffrey Liu
- Dalla Lana School of Public Health, University of Toronto
- George Davey Smith
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Rebecca C. Richmond
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- DOI
- https://doi.org/10.1038/s41467-020-19822-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Alcohol and smoking are both associated with oral/oropharyngeal cancer risk, but independent effects are unclear given their relatedness. Here, the authors use multivariable Mendelian randomization to show that both alcohol and smoking are independently causal for oral/oropharyngeal cancer.
