A Silicon-Based ROTE Sensor for High-Q and Label-Free Carcinoembryonic Antigen Detection

Luxiao Sang; Haojie Liang; Biao Zhao; Runze Shi; Aoqun Jian; Shengbo Sang

doi:10.3390/mi15050580

Micromachines (Apr 2024)

A Silicon-Based ROTE Sensor for High-Q and Label-Free Carcinoembryonic Antigen Detection

Luxiao Sang,
Haojie Liang,
Biao Zhao,
Runze Shi,
Aoqun Jian,
Shengbo Sang

Affiliations

Luxiao Sang: Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Haojie Liang: Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Biao Zhao: Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Runze Shi: Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Aoqun Jian: Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
Shengbo Sang: Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China

DOI: https://doi.org/10.3390/mi15050580
Journal volume & issue: Vol. 15, no. 5
p. 580

Abstract

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This paper presents a biosensor based on the resonant optical tunneling effect (ROTE) for detecting a carcinoembryonic antigen (CEA). In this design, sensing is accomplished through the interaction of the evanescent wave with the CEA immobilized on the sensor’s surface. When CEA binds to the anti-CEA, it alters the effective refractive index (RI) on the sensor’s surface, leading to shifts in wavelength. This shift can be identified through the cascade coupling of the FP cavity and ROTE cavity in the same mode. Experimental results further show that the shift in resonance wavelength increases with the concentration of CEA. The biosensor responded linearly to CEA concentrations ranging from 1 to 5 ng/mL with a limit of detection (LOD) of 0.5 ng/mL and a total Q factor of 9500. This research introduces a new avenue for identifying biomolecules and cancer biomarkers, which are crucial for early cancer detection.

Published in Micromachines

ISSN: 2072-666X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Mechanical engineering and machinery
Website: https://www.mdpi.com/journal/micromachines

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