Nature Communications (Mar 2022)
Divergent trajectories of antiviral memory after SARS-CoV-2 infection
- Adriana Tomic,
- Donal T. Skelly,
- Ane Ogbe,
- Daniel O’Connor,
- Matthew Pace,
- Emily Adland,
- Frances Alexander,
- Mohammad Ali,
- Kirk Allott,
- M. Azim Ansari,
- Sandra Belij-Rammerstorfer,
- Sagida Bibi,
- Luke Blackwell,
- Anthony Brown,
- Helen Brown,
- Breeze Cavell,
- Elizabeth A. Clutterbuck,
- Thushan de Silva,
- David Eyre,
- Sheila Lumley,
- Amy Flaxman,
- James Grist,
- Carl-Philipp Hackstein,
- Rachel Halkerston,
- Adam C. Harding,
- Jennifer Hill,
- Tim James,
- Cecilia Jay,
- Síle A. Johnson,
- Barbara Kronsteiner,
- Yolanda Lie,
- Aline Linder,
- Stephanie Longet,
- Spyridoula Marinou,
- Philippa C. Matthews,
- Jack Mellors,
- Christos Petropoulos,
- Patpong Rongkard,
- Cynthia Sedik,
- Laura Silva-Reyes,
- Holly Smith,
- Lisa Stockdale,
- Stephen Taylor,
- Stephen Thomas,
- Timothy Tipoe,
- Lance Turtle,
- Vinicius Adriano Vieira,
- Terri Wrin,
- OPTIC Clinical Group,
- PITCH Study Group,
- C-MORE Group,
- Andrew J. Pollard,
- Teresa Lambe,
- Chris P. Conlon,
- Katie Jeffery,
- Simon Travis,
- Philip Goulder,
- John Frater,
- Alex J. Mentzer,
- Lizzie Stafford,
- Miles W. Carroll,
- William S. James,
- Paul Klenerman,
- Eleanor Barnes,
- Christina Dold,
- Susanna J. Dunachie
Affiliations
- Adriana Tomic
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Donal T. Skelly
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Ane Ogbe
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Daniel O’Connor
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Matthew Pace
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Emily Adland
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Frances Alexander
- United Kingdom Health Security Agency, Porton Down
- Mohammad Ali
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Kirk Allott
- Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust
- M. Azim Ansari
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Sandra Belij-Rammerstorfer
- Jenner Institute, University of Oxford
- Sagida Bibi
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Luke Blackwell
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Anthony Brown
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Helen Brown
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Breeze Cavell
- United Kingdom Health Security Agency, Porton Down
- Elizabeth A. Clutterbuck
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Thushan de Silva
- The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield
- David Eyre
- Oxford University Hospitals NHS Foundation Trust
- Sheila Lumley
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Amy Flaxman
- Jenner Institute, University of Oxford
- James Grist
- Department of Physiology, Anatomy, and Genetics, University of Oxford
- Carl-Philipp Hackstein
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Rachel Halkerston
- United Kingdom Health Security Agency, Porton Down
- Adam C. Harding
- James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford
- Jennifer Hill
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Tim James
- Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust
- Cecilia Jay
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Síle A. Johnson
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Barbara Kronsteiner
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Yolanda Lie
- Monogram Biosciences LabCorp
- Aline Linder
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Stephanie Longet
- United Kingdom Health Security Agency, Porton Down
- Spyridoula Marinou
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Philippa C. Matthews
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Jack Mellors
- United Kingdom Health Security Agency, Porton Down
- Christos Petropoulos
- Monogram Biosciences LabCorp
- Patpong Rongkard
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Cynthia Sedik
- Monogram Biosciences LabCorp
- Laura Silva-Reyes
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Holly Smith
- Jenner Institute, University of Oxford
- Lisa Stockdale
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Stephen Taylor
- United Kingdom Health Security Agency, Porton Down
- Stephen Thomas
- United Kingdom Health Security Agency, Porton Down
- Timothy Tipoe
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Lance Turtle
- HPRU in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Vinicius Adriano Vieira
- Peter Medawar Building for Pathogen Research, Department of Paediatrics, University of Oxford
- Terri Wrin
- Monogram Biosciences LabCorp
- OPTIC Clinical Group
- PITCH Study Group
- C-MORE Group
- Andrew J. Pollard
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Teresa Lambe
- Jenner Institute, University of Oxford
- Chris P. Conlon
- Nuffield Department of Medicine, University of Oxford
- Katie Jeffery
- Oxford University Hospitals NHS Foundation Trust
- Simon Travis
- Oxford University Hospitals NHS Foundation Trust
- Philip Goulder
- Peter Medawar Building for Pathogen Research, Department of Paediatrics, University of Oxford
- John Frater
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Alex J. Mentzer
- Oxford University Hospitals NHS Foundation Trust
- Lizzie Stafford
- Nuffield Department of Medicine, University of Oxford
- Miles W. Carroll
- United Kingdom Health Security Agency, Porton Down
- William S. James
- James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford
- Paul Klenerman
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Eleanor Barnes
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- Christina Dold
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford
- Susanna J. Dunachie
- Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-022-28898-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.
