PROTEOMIC PROFILING IN OBSTETRIC PATHOLOGY

Abstract

Purpose: detects changes in proteomic spectrum of placenta at the complicated pregnancy.Materials and methods: 52 women are examined, of which the first group consisted of 15 women with uncomplicated pregnancy, the second - 19 women with fetal growth retardation (FGR), the third group consisted of 18 patients whose pregnancy was complicated by pre-eclampsia. Proteomic analysis of the placenta was performed using two-dimensional electrophoresis and time-of-flight mass spectrometry.Results: the conducted researches allowed to detect and identify proteins, the intensity of which production in complicated pregnancy is significantly different from that in physiological pregnancy. Comparative proteomic analysis of proteomic spectrum of placenta of women with FGR and preeclampsia also found intergroup differences.Summary: the revealed changes in the proteomic composition, obviously, reflect disturbances of molecular and cellular interactions in the placenta and have pathogenetic importance in formation of complicated pregnancy. The specifics of development of obstetric pathology may to some extent depend on differences proteomic spectrum.

Keywords

• proteomic analysis, placenta, pre-eclampsia, fetal growth retardation