Infection and Drug Resistance (Jun 2023)
Possible Role of Helicobacter pylori in Ear Nose and Throat Diseases
Abstract
Zaki F Aref,1 Shamardan Ezzeldin Sayed Bazeed,2 Asmaa Nafady,3 Dalia Fahim Mohammed Fahim,4 Ali A Ghweil,5 Mennatallah Ali Abdelrhman Sayed,6 Heba Mohammad Qubaisy,7 Mahmoud Khalefa,8 Usama A Arafa,9 Badawy Shahat Badawy,10 Ahmed Shawkat Abdelmohsen,11 Mohammed H Hassan,12 Aida A Abdelmaksoud1 1Department of ENT, Faculty of Medicine, South Valley University, Qena, Egypt; 2Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, Qena, Egypt; 3Department of Clinical and Chemical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt; 4Audiovestibular Medicine, Faculty of Medicine, Minia University, Minia, Egypt; 5Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, Qena, Egypt; 6King Salman International University, Faculty of Medicine, El Tor, Egypt; 7Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt; 8Department of ENT, Faculty of Medicine, Aswan University, Aswan, Egypt; 9Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt; 10Department of ENT, Faculty of Medicine, Luxor University, Luxor, Egypt; 11Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt; 12Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, 83523, EgyptCorrespondence: Mohammed H Hassan, Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, 83523, Egypt, Tel +20 1009097968, Email [email protected]; [email protected]: Helicobacter pylori is assumed to cause many gastric and extragastric diseases. We aimed to assess the possible association role of H. pylori in Otitis media with effusion (OME), nasal polyps and adenotonsillitis.Patients and Methods: A total of 186 patients with various ear, nose and throat diseases were included. The study comprised 78 children with chronic adenotonsillitis, 43 children with nasal polyps and 65 children with OME. OME patients were assigned to two subgroups: those who have and those who did not have adenoid hyperplasia. Among the patients with bilateral nasal polyps, 20 individuals had recurrent nasal polyps and 23 had de novo nasal polyps. Patients who have chronic adenotonsillitis were divided into three groups: those with chronic tonsillitis and those who underwent tonsillitis, those with chronic adenoiditis and adenoidectomy was performed, and those with chronic adenotonsillitis and underwent adenotonsillectomy. In addition to examination of H. pylori antigen in stool samples of all included patients, real-time polymerase chain reaction (RT-PCR) for detection of H. pylori in the effusion fluid was performed, additionally, Giemsa stain was used for detection of H. pylori organism within the tissue samples when available.Results: Frequency of H. pylori in effusion fluid was 28.6% in patients with OME and adenoid hyperplasia, while in those with OME it was only 17.4% with a p value of 0.2. Nasal polyp biopsies were positive in 13% patients of denovo, and 30% patients with recurrent nasal polyps, p=0.2. De novo nasal polyps were more prevalent in the positive stools than recurrent ones, p=0.7. All adenoid samples were negative for H. pylori, only two samples of tonsillar tissue (8.3%) were positive for H. pylori, and stool analysis was positive in 23 patients with chronic adenotonsillitis.Conclusion: Lack of association between Helicobacter pylori and occurrence of OME, nasal polyposis or recurrent adenotonsillitis.Keywords: Helicobacter pylori, otitis media with effusion, nasal polyps, adenotonsillitis
