Nature Communications (Nov 2020)
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
- Steven X. Cho,
- Ina Rudloff,
- Jason C. Lao,
- Merrin A. Pang,
- Rimma Goldberg,
- Christine B. Bui,
- Catriona A. McLean,
- Magdalena Stock,
- Tilman E. Klassert,
- Hortense Slevogt,
- Niamh E. Mangan,
- Wei Cheng,
- Doris Fischer,
- Stefan Gfroerer,
- Manjeet K. Sandhu,
- Devi Ngo,
- Alexander Bujotzek,
- Laurent Lariviere,
- Felix Schumacher,
- Georg Tiefenthaler,
- Friederike Beker,
- Clare Collins,
- C. Omar F. Kamlin,
- Kai König,
- Atul Malhotra,
- Kenneth Tan,
- Christiane Theda,
- Alex Veldman,
- Andrew M. Ellisdon,
- James C. Whisstock,
- Philip J. Berger,
- Claudia A. Nold-Petry,
- Marcel F. Nold
Affiliations
- Steven X. Cho
- Department of Paediatrics, Monash University
- Ina Rudloff
- Department of Paediatrics, Monash University
- Jason C. Lao
- Department of Paediatrics, Monash University
- Merrin A. Pang
- Department of Paediatrics, Monash University
- Rimma Goldberg
- Department of Paediatrics, Monash University
- Christine B. Bui
- Department of Paediatrics, Monash University
- Catriona A. McLean
- Department of Anatomical Pathology, Alfred Hospital
- Magdalena Stock
- ZIK Septomics, Jena University Hospital
- Tilman E. Klassert
- ZIK Septomics, Jena University Hospital
- Hortense Slevogt
- ZIK Septomics, Jena University Hospital
- Niamh E. Mangan
- Department of Molecular and Translational Science, Monash University
- Wei Cheng
- Department of Surgery, Beijing United Family Hospital
- Doris Fischer
- Department of Pediatrics, Goethe University Hospital
- Stefan Gfroerer
- Department of Pediatric Surgery, Goethe University Hospital
- Manjeet K. Sandhu
- Department of Paediatrics, Monash University
- Devi Ngo
- Department of Paediatrics, Monash University
- Alexander Bujotzek
- Roche Pharma Research and Early Development, Roche Innovation Center Munich
- Laurent Lariviere
- Roche Pharma Research and Early Development, Roche Innovation Center Munich
- Felix Schumacher
- Roche Pharma Research and Early Development, Roche Innovation Center Munich
- Georg Tiefenthaler
- Roche Pharma Research and Early Development, Roche Innovation Center Munich
- Friederike Beker
- Mater Research Institute, University of Queensland
- Clare Collins
- Neonatal Services, Mercy Hospital for Women
- C. Omar F. Kamlin
- Department of Newborn Research, Royal Women’s Hospital
- Kai König
- Medicum Wesemlin, Department of Paediatrics
- Atul Malhotra
- Department of Paediatrics, Monash University
- Kenneth Tan
- Department of Paediatrics, Monash University
- Christiane Theda
- Department of Newborn Research, Royal Women’s Hospital
- Alex Veldman
- Ritchie Centre, Hudson Institute of Medical Research
- Andrew M. Ellisdon
- Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
- James C. Whisstock
- Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
- Philip J. Berger
- Department of Paediatrics, Monash University
- Claudia A. Nold-Petry
- Department of Paediatrics, Monash University
- Marcel F. Nold
- Department of Paediatrics, Monash University
- DOI
- https://doi.org/10.1038/s41467-020-19400-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.
