Viruses (Jul 2020)

Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified <i>Vaccinia virus</i> Ankara (MVA)

  • Maurilia Marcacci,
  • Abdelmalik I. Khalafalla,
  • Zulaikha M. Al Hammadi,
  • Federica Monaco,
  • Cesare Cammà,
  • Mohammed F. Yusof,
  • Saeed M. Al Yammahi,
  • Iolanda Mangone,
  • Fabrizia Valleriani,
  • Mohamed A. Alhosani,
  • Nicola Decaro,
  • Alessio Lorusso,
  • Salama S. Almuhairi,
  • Giovanni Savini

DOI
https://doi.org/10.3390/v12080786
Journal volume & issue
Vol. 12, no. 8
p. 786

Abstract

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Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of morbidity and mortality, weight loss, and low milk yield. Prevention of camelpox is performed by vaccination. In this study, we investigated the composition of a CMLV-based, live-attenuated commercial vaccine using next-generation sequencing (NGS) technology. The results of this analysis revealed genomic sequences of Modified Vaccinia virus Ankara (MVA).

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