Nature Communications (Jul 2020)

Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance

  • Zengqin Deng,
  • Grigory Maksaev,
  • Angela M. Schlegel,
  • Jingying Zhang,
  • Michael Rau,
  • James A. J. Fitzpatrick,
  • Elizabeth S. Haswell,
  • Peng Yuan

DOI
https://doi.org/10.1038/s41467-020-17538-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Mechanosensitive channels transduce physical force into electrochemical signaling in processes such as hearing, touch, proprioception, osmoregulation, and morphogenesis. Here, authors use cryo-electron microscopy to provide structural insights into the mechanical gating mechanism.