A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder

Thomas L. Athey; Thomas L. Athey; Thomas L. Athey; Can Ceritoglu; Daniel J. Tward; Daniel J. Tward; Daniel J. Tward; Kwame S. Kutten; J. Raymond DePaulo; Kara Glazer; Fernando S. Goes; John R. Kelsoe; John R. Kelsoe; Francis Mondimore; Caroline M. Nievergelt; Kelly Rootes-Murdy; Peter P. Zandi; Peter P. Zandi; J. Tilak Ratnanather; J. Tilak Ratnanather; J. Tilak Ratnanather; Pamela B. Mahon; Pamela B. Mahon; Pamela B. Mahon

doi:10.3389/fpsyt.2021.614010

Frontiers in Psychiatry (Feb 2021)

A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder

Thomas L. Athey,
Thomas L. Athey,
Thomas L. Athey,
Can Ceritoglu,
Daniel J. Tward,
Daniel J. Tward,
Daniel J. Tward,
Kwame S. Kutten,
J. Raymond DePaulo,
Kara Glazer,
Fernando S. Goes,
John R. Kelsoe,
John R. Kelsoe,
Francis Mondimore,
Caroline M. Nievergelt,
Kelly Rootes-Murdy,
Peter P. Zandi,
Peter P. Zandi,
J. Tilak Ratnanather,
J. Tilak Ratnanather,
J. Tilak Ratnanather,
Pamela B. Mahon,
Pamela B. Mahon,
Pamela B. Mahon

Affiliations

Thomas L. Athey: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States
Thomas L. Athey: Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States
Thomas L. Athey: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States
Can Ceritoglu: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States
Daniel J. Tward: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States
Daniel J. Tward: Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States
Daniel J. Tward: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States
Kwame S. Kutten: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States
J. Raymond DePaulo: Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States
Kara Glazer: Department of Occupational Therapy, Boston University, Boston, MA, United States
Fernando S. Goes: Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States
John R. Kelsoe: Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, United States
John R. Kelsoe: Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
Francis Mondimore: Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States
Caroline M. Nievergelt: Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
Kelly Rootes-Murdy: Department of Psychology, Georgia State University, Atlanta, GA, United States
Peter P. Zandi: Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States
Peter P. Zandi: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
J. Tilak Ratnanather: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, United States
J. Tilak Ratnanather: Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States
J. Tilak Ratnanather: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States
Pamela B. Mahon: Department of Psychiatry and Behavioral Science, Johns Hopkins School of Medicine, Baltimore, MD, United States
Pamela B. Mahon: 0Department of Psychiatry, Brigham & Women's Hospital, Boston, MA, United States
Pamela B. Mahon: 1Department of Psychiatry, Harvard School of Medicine, Boston, MA, United States

DOI: https://doi.org/10.3389/fpsyt.2021.614010
Journal volume & issue: Vol. 12

Abstract

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Research to discover clinically useful predictors of lithium response in patients with bipolar disorder has largely found them to be elusive. We demonstrate here that detailed neuroimaging may have the potential to fill this important gap in mood disorder therapeutics. Lithium treatment and bipolar disorder have both been shown to affect anatomy of the hippocampi and amygdalae but there is no consensus on the nature of their effects. We aimed to investigate structural surface anatomy changes in amygdala and hippocampus correlated with treatment response in bipolar disorder. Patients with bipolar disorder (N = 14) underwent lithium treatment, were classified by response status at acute and long-term time points, and scanned with 7 Tesla structural MRI. Large Deformation Diffeomorphic Metric Mapping was applied to detect local differences in hippocampal and amygdalar anatomy between lithium responders and non-responders. Anatomy was also compared to 21 healthy comparison participants. A patch of the ventral surface of the left hippocampus was found to be significantly atrophied in non-responders as compared to responders at the acute time point and was associated at a trend-level with long-term response status. We did not detect an association between response status and surface anatomy of the right hippocampus or amygdala. To the best of our knowledge, this is the first shape analysis of hippocampus and amygdala in bipolar disorder using 7 Tesla MRI. These results can inform future work investigating possible neuroimaging predictors of lithium response in bipolar disorder.

Published in Frontiers in Psychiatry

ISSN: 1664-0640 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.frontiersin.org/journals/psychiatry

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