A Homozygous Deletion of the DPY19L2 Gene is a Cause of Globozoospermia in Men From the Republic of Macedonia

Abstract

Globozoospermia is a rare but severe teratozoospermia, characterized by ejaculates consisting completely of round-headed spermatozoa that lack an acrosome or, in partial globozoospermia, containing a variable proportion (20.0-90.0%) of acrosomeless spermatozoa. Men that are affected with total globozoospermia are infertile, and even the application of intracytoplasmic sperm injection (ICSI) has met with disappointingly low success rates.

Keywords

• globozoospermia
• dpy19l2 gene
• intra cytoplasmic sperm injection (icsi)
• nonallelic homologous recombination (nahr)
• low copy repeats (lcrs)
• deletion(s)
• male infertility