Clinical, Cosmetic and Investigational Dermatology (Dec 2021)

Efficacy of Heparinoid Cream Containing Pseudo-Ceramide for Remission of Atopic Dermatitis

  • Matsuoka M,
  • Okoshi K,
  • Ito S,
  • Kume T,
  • Seki T,
  • Nishizaka T,
  • Okada J,
  • Nagasawa A,
  • Iijima M,
  • Abe M,
  • Nemoto O

Journal volume & issue
Vol. Volume 14
pp. 1839 – 1847


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Megumi Matsuoka,1 Keita Okoshi,1 Shotaro Ito,1 Takuji Kume,2 Tsuyoshi Seki,1 Takahiro Nishizaka,1 Joji Okada,3 Azumi Nagasawa,1 Makoto Iijima,1 Masatoshi Abe,4 Osamu Nemoto4 1Health & Wellness Products Research, Kao Corporation, Sumida-ku, Tokyo, Japan; 2Analytical Science Research, Kao Corporation, Wakayama, Japan; 3Skin Care Products Research, Kao Corporation, Sumida-ku, Tokyo, Japan; 4Sapporo Skin Clinic, Sapporo, Hokkaido, JapanCorrespondence: Azumi NagasawaHealth & Wellness Products Research, Kao Corporation, 2-1-3, Bunka, Sumida-ku, Tokyo, 131-8501, JapanTel +81-3-5630-9443Fax +81-3-5630-9342Email nagasawa.azu[email protected]: Atopic dermatitis (AD) is characterized by chronic inflammation, which frequently recurs, is exacerbated, and enters remission. A maintenance remission period is important for AD patients. We developed a formulation for use during AD remission, containing heparinoid and pseudo-ceramide that forms a lamellar structure. We evaluated the allergen permeability and examined the formulation’s efficacy in maintaining remission in patients with AD.Materials and Methods: Seventeen AD patients applied a cream containing 0.3% heparinoid and pseudo-ceramide (test cream group, n = 10), or a general cream containing 0.3% heparinoid (control cream group, n = 7) to their arm for four weeks after inducing remission with the application of a steroid cream for two weeks.Results: The lamellar structure of the test cream was confirmed with small- and wide-angle x-ray scattering analysis and observation by transmission electron microscopy. The test cream inhibited the penetration of V8 protease significantly compared to the control cream in vitro. According to AD severity score by dermatologists, the effects remission maintenance of the test cream group were comparable to those of the control cream group. However, the test cream group had a significantly increased skin hydration value compared to the control cream group. A significant decrease in transepidermal water loss, an indicator of skin barrier function, was shown in the test cream group compared to the control cream group.Conclusion: The cream with lamellar structures containing heparinoid and pseudo-ceramides may inhibit allergen penetration. Moreover, skin properties improved during the remission period; thus, the formulation we developed was suitable for use during the AD remission period.Keywords: atopic dermatitis, barrier, lamellar, heparinoid, ceramide, skin hydration, transepidermal water loss