Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo; Elodie Viry; Etienne Moussay; Jerome Paggetti

doi:10.1080/2162402X.2022.2127507

OncoImmunology (Dec 2022)

Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo,
Elodie Viry,
Etienne Moussay,
Jerome Paggetti

Affiliations

Ernesto Gargiulo: Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg
Elodie Viry: Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg
Etienne Moussay: Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg
Jerome Paggetti: Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg

DOI: https://doi.org/10.1080/2162402X.2022.2127507
Journal volume & issue: Vol. 11, no. 1

Abstract

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Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

Published in OncoImmunology

ISSN: 2162-402X (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.tandfonline.com/journals/koni

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Abstract

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