Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
Pier Paolo Piccaluga,
Mohsen Navari,
Axel Visani,
Flavia Rigotti,
Claudio Agostinelli,
Simona Righi,
Erica Diani,
Marco Ligozzi,
Maria Carelli,
Cristina Ponti,
Isabella Bon,
Donato Zipeto,
Santo Landolfo,
Davide Gibellini
Affiliations
Pier Paolo Piccaluga
Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy; Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST) Palermo, Italy; Department of Pathology, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya; Corresponding author.
Mohsen Navari
Department of Medical Biotechnology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Bioinformatics Research Group, Mashhad University of Medical Sciences, Mashhad, Iran
Axel Visani
Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy
Flavia Rigotti
Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy
Claudio Agostinelli
Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy
Simona Righi
Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy
Erica Diani
Department of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy
Marco Ligozzi
Department of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy
Maria Carelli
Department of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy
Cristina Ponti
Department of Life Sciences, University of Trieste, Trieste, Italy
Isabella Bon
Department of Experimental, Diagnostic, and Specialty Medicine, Microbiology Unit, University of Bologna, Bologna, Italy
Donato Zipeto
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
Santo Landolfo
Department of Public Health and Microbiology, University of Turin, Turin, Italy
Davide Gibellini
Department of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy
IFI16, member of the IFN-inducible PYHIN-200 gene family, modulates proliferation, survival and differentiation of different cell lineages. In particular, IFI16 expression, which is regulated during the differentiation of B cells, was recently studied in B-CLL as well. Here, we compared IFI16 expression in several lymphomas including Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma with respect to normal cell counterparts. We observed that IFI16 expression was significantly deregulated only in mantle cell lymphoma (p < 0.05). Notably, IFI16 was associated with the expression of genes involved in interferon response, cell cycle, cell death and proliferation and, interestingly, lipid and glucose metabolism, suggesting that IFI16 deregulation might be associated with relevant changes in cell biology. In our group of mantle cell lymphoma samples a correlation between patient survival and IFI16 expression was not detected even though mantle cell lymphoma prognosis is known to be associated with cell proliferation. Altogether, these results suggest a complex relationship between IFI16 expression and MCL which needs to be analyzed in further studies.
