Nature Communications (Jul 2021)

Correlation of membrane protein conformational and functional dynamics

  • Raghavendar Reddy Sanganna Gari,
  • Joel José Montalvo‐Acosta,
  • George R. Heath,
  • Yining Jiang,
  • Xiaolong Gao,
  • Crina M. Nimigean,
  • Christophe Chipot,
  • Simon Scheuring

DOI
https://doi.org/10.1038/s41467-021-24660-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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High-speed atomic force microscopy height spectroscopy and single channel electrophysiology recordings are used to correlate conformational and functional dynamics of the model membrane protein, outer membrane protein G (OmpG). These techniques show that both states coexist and rapidly interchange in all conditions supported by molecular dynamics simulations.