Gene expression of cytokines and prostaglandin metabolism–related proteins in eosinophilic otitis media

Aiko Oka, MD; Masahiro Takahashi, MD; Wataru Nishimura, MD, PhD; Shogo Oyamada, MD; Shinichiro Oka, MD; Satoshi Iwasaki, MD; Kengo Kanai, MD; Mitsuhiro Okano, MD

Journal of Allergy and Clinical Immunology: Global (May 2024)

Gene expression of cytokines and prostaglandin metabolism–related proteins in eosinophilic otitis media

Aiko Oka, MD,
Masahiro Takahashi, MD,
Wataru Nishimura, MD, PhD,
Shogo Oyamada, MD,
Shinichiro Oka, MD,
Satoshi Iwasaki, MD,
Kengo Kanai, MD,
Mitsuhiro Okano, MD

Affiliations

Aiko Oka, MD: Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan; Corresponding author: Aiko Oka, MD, 852 Hatakeda, Narita, Chiba Prefecture 286-8520, Japan.
Masahiro Takahashi, MD: Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan
Wataru Nishimura, MD, PhD: Department of Molecular Biology, International University of Health and Welfare School of Medicine, Narita, Japan
Shogo Oyamada, MD: Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan
Shinichiro Oka, MD: Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan
Satoshi Iwasaki, MD: Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan
Kengo Kanai, MD: Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan
Mitsuhiro Okano, MD: Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan

Journal volume & issue: Vol. 3, no. 2
p. 100237

Abstract

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The objective of this study was to investigate the levels of gene expression in the middle ear mucosa of 2 patients diagnosed with eosinophilic otitis media. One patient with severe hearing loss showed high expression levels of genes encoding IL-5 and IL-33 receptors.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

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