Nature Communications (Mar 2017)
Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
- Halime Kalkavan,
- Piyush Sharma,
- Stefan Kasper,
- Iris Helfrich,
- Aleksandra A. Pandyra,
- Asmae Gassa,
- Isabel Virchow,
- Lukas Flatz,
- Tim Brandenburg,
- Sukumar Namineni,
- Mathias Heikenwalder,
- Bastian Höchst,
- Percy A. Knolle,
- Guido Wollmann,
- Dorothee von Laer,
- Ingo Drexler,
- Jessica Rathbun,
- Paula M. Cannon,
- Stefanie Scheu,
- Jens Bauer,
- Jagat Chauhan,
- Dieter Häussinger,
- Gerald Willimsky,
- Max Löhning,
- Dirk Schadendorf,
- Sven Brandau,
- Martin Schuler,
- Philipp A. Lang,
- Karl S. Lang
Affiliations
- Halime Kalkavan
- Institute of Immunology, Medical Faculty, University Duisburg-Essen
- Piyush Sharma
- Institute of Immunology, Medical Faculty, University Duisburg-Essen
- Stefan Kasper
- Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen
- Iris Helfrich
- Department of Dermatology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen
- Aleksandra A. Pandyra
- Institute of Immunology, Medical Faculty, University Duisburg-Essen
- Asmae Gassa
- Institute of Immunology, Medical Faculty, University Duisburg-Essen
- Isabel Virchow
- Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen
- Lukas Flatz
- Department of Dermatology/Allergology, Cantonal Hospital
- Tim Brandenburg
- Institute of Immunology, Medical Faculty, University Duisburg-Essen
- Sukumar Namineni
- Department of Virology, Technical University of Munich
- Mathias Heikenwalder
- Department of Virology, Technical University of Munich
- Bastian Höchst
- Institute of Molecular Immunology/Experimental Oncology, München Klinikum rechts der Isar, Technical University Munich
- Percy A. Knolle
- Institute of Molecular Immunology/Experimental Oncology, München Klinikum rechts der Isar, Technical University Munich
- Guido Wollmann
- Division for Virology, Medical University Innsbruck
- Dorothee von Laer
- Division for Virology, Medical University Innsbruck
- Ingo Drexler
- Institute of Virology, Düsseldorf University Hospital, Heinrich Heine University
- Jessica Rathbun
- Department of Molecular Microbiology and Immunology, University of Southern California
- Paula M. Cannon
- Department of Molecular Microbiology and Immunology, University of Southern California
- Stefanie Scheu
- Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf
- Jens Bauer
- Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf
- Jagat Chauhan
- Ludwig Institute for Cancer Research, University of Oxford
- Dieter Häussinger
- Department of Gastroenterology, Hepatology and Infectious Diseases, University of Düsseldorf
- Gerald Willimsky
- Institute of Immunology (Charité - University Medicine Berlin)
- Max Löhning
- Department of Rheumatology and Clinical Immunology, Charité—University Medicine Berlin and German Rheumatism Research Center (DRFZ)
- Dirk Schadendorf
- Department of Dermatology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen
- Sven Brandau
- Department of Otorhinolaryngology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen
- Martin Schuler
- Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen
- Philipp A. Lang
- Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University
- Karl S. Lang
- Institute of Immunology, Medical Faculty, University Duisburg-Essen
- DOI
- https://doi.org/10.1038/ncomms14447
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing monocytes.
