Frontiers in Genetics (Jan 2022)
Emerging Roles for LGR4 in Organ Development, Energy Metabolism and Carcinogenesis
- Linlin Yang,
- Linlin Yang,
- Linlin Yang,
- Jing Wang,
- Jing Wang,
- Jing Wang,
- Xiaodi Gong,
- Xiaodi Gong,
- Xiaodi Gong,
- Qiong Fan,
- Qiong Fan,
- Qiong Fan,
- Xiaoming Yang,
- Xiaoming Yang,
- Xiaoming Yang,
- Yunxia Cui,
- Yunxia Cui,
- Yunxia Cui,
- Xiaoyan Gao,
- Xiaoyan Gao,
- Xiaoyan Gao,
- Lijuan Li,
- Lijuan Li,
- Lijuan Li,
- Xiao Sun,
- Xiao Sun,
- Xiao Sun,
- Yuhong Li,
- Yuhong Li,
- Yuhong Li,
- Yudong Wang,
- Yudong Wang,
- Yudong Wang
Affiliations
- Linlin Yang
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Linlin Yang
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Linlin Yang
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Jing Wang
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Jing Wang
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Jing Wang
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Xiaodi Gong
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xiaodi Gong
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Xiaodi Gong
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Qiong Fan
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Qiong Fan
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Qiong Fan
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Xiaoming Yang
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xiaoming Yang
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Xiaoming Yang
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Yunxia Cui
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Yunxia Cui
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Yunxia Cui
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Xiaoyan Gao
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xiaoyan Gao
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Xiaoyan Gao
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Lijuan Li
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Lijuan Li
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Lijuan Li
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Xiao Sun
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Xiao Sun
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Xiao Sun
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Yuhong Li
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Yuhong Li
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Yuhong Li
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- Yudong Wang
- Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- Yudong Wang
- Shanghai Municipal Key Clinical Specialty, Shanghai, China
- Yudong Wang
- Shanghai Key Laboratory of Embryo Original Disease, Shanghai, China
- DOI
- https://doi.org/10.3389/fgene.2021.728827
- Journal volume & issue
-
Vol. 12
Abstract
The leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) belonging to G protein-coupled receptors (GPCRs) family, had various regulatory roles at multiple cellular types and numerous targeting sites, and aberrant LGR4 signaling played crucial roles in diseases and carcinogenesis. On the basis of these facts, LGR4 may become an appealing therapeutic target for the treatment of diseases and tumors. However, a comprehensive investigation of its functions and applications was still lacking. Hence, this paper provided an overview of the molecular characteristics and signaling mechanisms of LGR4, its involvement in multiple organ development and participation in the modulation of immunology related diseases, metabolic diseases, and oxidative stress damage along with cancer progression. Given that GPCRs accounted for almost a third of current clinical drug targets, the in-depth understanding of the sophisticated connections of LGR4 and its ligands would not only enrich their regulatory networks, but also shed new light on designing novel molecular targeted drugs and small molecule blockers for revolutionizing the treatment of various diseases and tumors.
Keywords
