Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent

• Mingwei Fu,
• Min Ge,
• Wanxiang Yang,
• Chunchen Hu,
• Xiaowei Li,
• Yuanjiang Wang,
• Shaohua Gou

Affiliations

Mingwei Fu

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Zenji Research Laboratories, Nanjing 211189, China

Min Ge

Zenji Research Laboratories, Nanjing 211189, China

Wanxiang Yang

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, China

Chunchen Hu

Zenji Research Laboratories, Nanjing 211189, China

Xiaowei Li

Zenji Research Laboratories, Nanjing 211189, China

Yuanjiang Wang

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, China; Corresponding authors.

Shaohua Gou

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, China; Corresponding authors.