Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Trinidad Montero-Melendez; Ai Nagano; Claude Chelala; Andrew Filer; Christopher D. Buckley; Mauro Perretti

doi:10.1038/s41467-020-14421-x

Nature Communications (Feb 2020)

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Trinidad Montero-Melendez,
Ai Nagano,
Claude Chelala,
Andrew Filer,
Christopher D. Buckley,
Mauro Perretti

Affiliations

Trinidad Montero-Melendez: The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London
Ai Nagano: Barts Cancer Institute, Barts and The London School of Medicine, Queen Mary University of London
Claude Chelala: Barts Cancer Institute, Barts and The London School of Medicine, Queen Mary University of London
Andrew Filer: NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Institute of Inflammation and Ageing
Christopher D. Buckley: NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Institute of Inflammation and Ageing
Mauro Perretti: The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London

DOI: https://doi.org/10.1038/s41467-020-14421-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Fibroblast hyper-activation and proliferation is a major feature in arthritis, yet scarcely addressed for anti-arthritic therapies. Here, the authors show that activation of the MC1 receptor induces fibroblast senescence associated with a reparative phenotype, ultimately regulating experimental inflammatory arthritis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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