HETEROLOGOUS TRANSPLANTATION OF BOVINE ETHMOID CARCINOMA CELLS USING CYCLOSPORINE-A

Abstract

A study was undertaken to transplant bovine ethmoid tumour cells into different heterologous species of animals using CS-A. Transplanted tumours offer an excellent model system for evaluating immunoprophylactic measures, chemo-sensitivity and tumour metastasis. Trypsinized single cell suspension of fresh bovine ethmoid tumour was inoculated subcutaneously into immunosuppressed rats, mice and rabbits. The animals were observed for 30 days. At the end of the period the animals were sacrificed and site of inoculation was taken for histopathology. Transplantation was attained for the first time. The tumour growth was observed as an oval to round mass embedded in the subcutaneous fat. The haematological studies were also due to evaluate the immuno-competency of the animals.