The Correlation Between Single Nucleotide Polymorphism Patterns and Colorectal Cancer in the Iranian Population

Abstract

Context: The incidence of colorectal cancer has significantly increased in Iran during the last decade. Accumulating evidence suggeststhat there is a significant correlation between genetic variations such as polymorphisms and colorectal cancer. Therefore,identification of critical polymorphisms related to colorectal cancer can contribute to find individuals at high risk of CRC.Evidence Acquisition: The focus of this review was on published articles in English about the association between different singlenucleotide polymorphisms and colorectal cancer in the Iranian population. Evidences were gathered by searching online medicaldatabases including Google scholar, Pubmed, Scopus and Science Direct.Conclusions: Various single nucleotide polymorphisms of critical genes indicated significant association with colorectal cancer inthe Iranian population. New polymorphism markers for high risk individuals have been recognized through further investigationsto reduce the incidence and mortality of colorectal cancer.

Keywords

• single nucleotide polymorphism
• colorectal cancer
• iranian population