Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

Vaibhav Sidarala; Jie Zhu; Elena Levi-D’Ancona; Gemma L. Pearson; Emma C. Reck; Emily M. Walker; Brett A. Kaufman; Scott A. Soleimanpour

doi:10.1038/s41467-022-29945-7

Nature Communications (Apr 2022)

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

Vaibhav Sidarala,
Jie Zhu,
Elena Levi-D’Ancona,
Gemma L. Pearson,
Emma C. Reck,
Emily M. Walker,
Brett A. Kaufman,
Scott A. Soleimanpour

Affiliations

Vaibhav Sidarala: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan
Jie Zhu: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan
Elena Levi-D’Ancona: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan
Gemma L. Pearson: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan
Emma C. Reck: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan
Emily M. Walker: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan
Brett A. Kaufman: Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine
Scott A. Soleimanpour: Division of Metabolism, Endocrinology & Diabetes and Department of Internal Medicine, University of Michigan

DOI: https://doi.org/10.1038/s41467-022-29945-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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