Düzce Üniversitesi Bilim ve Teknoloji Dergisi (Jan 2019)
Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine
Abstract
This paper presents anti-urease and antibacterial activities of chloropheniramine maleat, paracetamol and clarithromycine. Antibacterial activity of the compounds was investigated against Salmonella enterica, Enterobacter aerogenes, Bacillus subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae and Enterococcus faecalis. Moreover, anti-urease activity of the compounds was searched. All tested compounds demonstrated antibacterial action with varying degree except for chloropheniramine maleat. Chloropheniramine maleat, paracetamol and chlarithromycine exhibited higher activity than thiourea. The data obtained from the study, chloropheniramine maleate, paracetamol and clarithromycin are thought to be useful as new urease inhibitors and the present study should be supported by further studies. Furthermore, it is thought that paracetamol has antibacterial properties and therefore can be used as an alternative to antibiotics
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