Metabolic linkages between indoor negative air ions, particulate matter and cardiorespiratory function: A randomized, double-blind crossover study among children

Shan Liu; Qingyu Huang; Yan Wu; Yi Song; Wei Dong; Mengtian Chu; Di Yang; Xi Zhang; Jie Zhang; Chen Chen; Bin Zhao; Heqing Shen; Xinbiao Guo; Furong Deng

Environment International (May 2020)

Metabolic linkages between indoor negative air ions, particulate matter and cardiorespiratory function: A randomized, double-blind crossover study among children

Shan Liu,
Qingyu Huang,
Yan Wu,
Yi Song,
Wei Dong,
Mengtian Chu,
Di Yang,
Xi Zhang,
Jie Zhang,
Chen Chen,
Bin Zhao,
Heqing Shen,
Xinbiao Guo,
Furong Deng

Affiliations

Shan Liu: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Qingyu Huang: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
Yan Wu: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
Yi Song: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China
Wei Dong: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Mengtian Chu: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Di Yang: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Xi Zhang: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
Jie Zhang: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China
Chen Chen: Department of Building Science, School of Architecture, Tsinghua University, Beijing 100084, China
Bin Zhao: Department of Building Science, School of Architecture, Tsinghua University, Beijing 100084, China
Heqing Shen: Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China; Corresponding authors at: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, No. 38 Xueyuan Road, Beijing 100191, China (F. Deng). State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 Xiang An Nan Road, 361102, Xiamen, China (H. Shen).
Xinbiao Guo: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Furong Deng: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Corresponding authors at: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, No. 38 Xueyuan Road, Beijing 100191, China (F. Deng). State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 Xiang An Nan Road, 361102, Xiamen, China (H. Shen).

Journal volume & issue: Vol. 138

Abstract

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Background: Ionization air purifiers, which purify particulate matter (PM) by producing vast number of negative air ions (NAI), are widely used. Recent study implied that ionization air purification could bring respiratory benefits but deterioration of heart rate variability (HRV). However, its underlying molecular mechanisms remain unclear. Objectives: To explore the molecular linkages between indoor NAI, decreased PM and the cardiorespiratory effect after purification. Methods: Urine samples were collected from 44 healthy children three times of each study period (real and sham purification) in an existing randomized, double-blind crossover study. Ultra-high performance liquid chromatography/mass spectrometry was conducted in metabolomics analysis, the associations between indoor NAI, decreased PM and the cardiorespiratory function were investigated via the meet-in-metabolite approach (MIMA) based on statistical and metabolic pathway analysis. Mixed-effect models were used to establish associations between exposure, health parameters and metabolites. Results: Twenty-eight and fourteen metabolites were identified with significant correlations to NAI and PM, respectively. Besides, eight and eighteen metabolites were separately associated with respiratory function and HRV. The increased NAI and decreased PM improved respiratory function mainly with eight pathways, promoting energy production, anti-inflammation and anti-oxidation capacity. Decreased PM ameliorated HRV with six main pathways, increasing energy production and anti-inflammation capacity while increased NAI deteriorated HRV with five main pathways, lowering energy generation and anti-oxidation capacity. Conclusions: Increased NAI and decreased PM ameliorated respiratory function by increasing energy production, improving anti-inflammation and anti-oxidation capacity. Decreased PM improved cardiac autonomic function by increasing energy production and anti-inflammation capacity, while these benefits were overcast by massive NAI via lowering energy generation and anti-oxidation capacity with different metabolic pathways. Keywords: Negative air ion, Particulate matter, Metabolomics, Cardiorespiratory function, Children

Published in Environment International

ISSN: 0160-4120 (Print)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environment-international

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