Drug-loaded electrospun nanofiber for Vulvovaginal candidiasis: A systematic literature review

Abstract

Purpose: This study decodes the role of electrospun nanofibers in the treatment of VVC. Result: 7 out of 8 included studies were basic research with in vitro data and one of them showed in vivo data. All of the included articles showcased the mucoadhesive nature of nanofibers with good tensile strength, good drug absorption with improved bioavailability, and sustained drug release with better therapeutic activity than other formulations. Conclusion: Nanofibers found as a potential carrier that overcomes the constraints of the conventional formulations for the delivery of drugs in the vagina and warranted an effective treatment for VVC.

Keywords

• Nanofibers
• Electrospun
• Vulvovaginal candidiasis
• Drug delivery
• Polymer