Diagnostic Pathology (May 2010)

Pelvic skeletal metastasis of hepatocellular carcinoma with sarcomatous change: a case report

  • Lin Wei-Hsin,
  • Lan Tsung-Yu,
  • Hsueh Yong-Te,
  • Chen Chih-Yu,
  • Wu Karl,
  • Yang Rong-Sen

DOI
https://doi.org/10.1186/1746-1596-5-33
Journal volume & issue
Vol. 5, no. 1
p. 33

Abstract

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Abstract Sarcomatoid hepatocellular carcinoma (HCC) is a very rare histologic variant of HCC. The characteristic of skeletal metastatic sarcomatoid hepatocellular carcinoma has never been reported. We reported a patient with sarcomatoid hepatocellular carcinoma pelvic metastasis who presented with huge pelvic metastasis that had relatively small osteolytic lesion centrally located accompanied by huge bipeduncular invasive expansile lesions into surrounding soft tissue. The lesion showed almost non-isotope uptake in 99mTc-methylene diphosphonate bone scintigraphy study. He underwent radiotherapy and tumor excision but the tumor rapidly recurred. In addition, serum α-fetoprotein level was never elevated beyond normal limit (