Nature Communications (Jul 2022)
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
- Mark J. Wall,
- Emily Hill,
- Robert Huckstepp,
- Kerry Barkan,
- Giuseppe Deganutti,
- Michele Leuenberger,
- Barbara Preti,
- Ian Winfield,
- Sabrina Carvalho,
- Anna Suchankova,
- Haifeng Wei,
- Dewi Safitri,
- Xianglin Huang,
- Wendy Imlach,
- Circe La Mache,
- Eve Dean,
- Cherise Hume,
- Stephanie Hayward,
- Jess Oliver,
- Fei-Yue Zhao,
- David Spanswick,
- Christopher A. Reynolds,
- Martin Lochner,
- Graham Ladds,
- Bruno G. Frenguelli
Affiliations
- Mark J. Wall
- School of Life Sciences, University of Warwick
- Emily Hill
- School of Life Sciences, University of Warwick
- Robert Huckstepp
- School of Life Sciences, University of Warwick
- Kerry Barkan
- Department of Pharmacology, University of Cambridge
- Giuseppe Deganutti
- Centre for Sport, Exercise and Life Sciences (CSELS), Faculty of Health and Life Sciences, Coventry University
- Michele Leuenberger
- Institute of Biochemistry and Molecular Medicine, University of Bern
- Barbara Preti
- Institute of Biochemistry and Molecular Medicine, University of Bern
- Ian Winfield
- Department of Pharmacology, University of Cambridge
- Sabrina Carvalho
- Department of Pharmacology, University of Cambridge
- Anna Suchankova
- Department of Pharmacology, University of Cambridge
- Haifeng Wei
- NeuroSolutions Ltd
- Dewi Safitri
- Department of Pharmacology, University of Cambridge
- Xianglin Huang
- Department of Pharmacology, University of Cambridge
- Wendy Imlach
- Department of Physiology, Monash Biomedicine Discovery Institute, Monash University
- Circe La Mache
- School of Life Sciences, University of Warwick
- Eve Dean
- School of Life Sciences, University of Warwick
- Cherise Hume
- School of Life Sciences, University of Warwick
- Stephanie Hayward
- School of Life Sciences, University of Warwick
- Jess Oliver
- School of Life Sciences, University of Warwick
- Fei-Yue Zhao
- NeuroSolutions Ltd
- David Spanswick
- NeuroSolutions Ltd
- Christopher A. Reynolds
- Centre for Sport, Exercise and Life Sciences (CSELS), Faculty of Health and Life Sciences, Coventry University
- Martin Lochner
- Institute of Biochemistry and Molecular Medicine, University of Bern
- Graham Ladds
- Department of Pharmacology, University of Cambridge
- Bruno G. Frenguelli
- School of Life Sciences, University of Warwick
- DOI
- https://doi.org/10.1038/s41467-022-31652-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-reaching concept of selective Gα agonism.
