Molecules (Jul 2012)

Evaluation of Antioxidant and Immunity-Enhancing Activities of <em>Sargassum pallidum</em> Aqueous Extract in Gastric Cancer Rats

  • Shen-Kang Zhou,
  • Tie-Nan Bi,
  • Wen-Da Luo,
  • Rui-Li Zhang

DOI
https://doi.org/10.3390/molecules17078419
Journal volume & issue
Vol. 17, no. 7
pp. 8419 – 8429

Abstract

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The effect of <em>Sargassum pallidum</em> (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with <em>Sargassum pallidum</em> aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against <em>N</em>-methyl-<em>N′</em>-nitro-<em>N</em>-nitrosoguanidine (MNNG)-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10) levels, decreasing interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that <em>Sargassum pallidum</em> aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats.

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