Some issues of the diagnosis and treatment of gastroesophageal reflux disease

Abstract

The clinical inefficacy of proton pump inhibitors (PPIs) is very frequently encountered in nonerosive gastroesophageal reflux disease (NERD) in particular. Postprandial acid pocket, weak-acid or alkaline reflux, etc. are one of the causes of resistance to antisecretory drugs. Alginates serve as a good alternative to PPIs in treating NERD and gastroesophageal reflux in children and pregnant women. The alginate test may help diagnose NERD.

Keywords

• gastroesophageal reflux disease
• nonerosive reflux disease
• heartburn
• postprandial acid pocket
• alginates