Fibroblast-Mimicking nanodecoys for Multi-Target antiangiogenesis in the inflammation treatment

Abstract

Localized inhibition of angiogenesis is an attractive therapeutic strategy for exogenous mediators-induced inflammation. Here, inspired by the unique biointerface of the natural cell membrane, we develop an endogenous cell membrane-derived biomimetic nanosystem (fibroblast membrane-camouflaged nanoparticles, FB@NPs) for blocking angiogenesis in the lipopolysaccharides (LPS)-induced inflammatory process. The fibroblast membrane coating provides as-fabricated nanoparticles with potent and specific binding ability to LPS, diverting these pathological toxins away and protecting resident fibroblasts. By efficient LPS neutralization and elimination, FB@NPs inhibit the production of a number of cross-regulated pro-angiogenic factors, and thereby greatly block inflammatory neovascularization. Besides, due to the self-recognition capability and inherent remarkable biocompatibility of these endogenous biomimetic nanoparticles, FB@NPs show highly desirable biosafety during the antiangiogenesis process in inflammation treatment. In summary, the novel exploration provides a promising route for developing next-generation biomimetic antiangiogenic nanoplatform.

Keywords

• Neovascularization
• LPS-induced inflammation
• Antiangiogenesis
• Fibroblast membrane-camouflaged nanoparticle
• Pro-angiogenic factor