Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

Junyeop Lee; Keewon Sung; So Young Joo; Jun-Hyeon Jeong; Seong Keun Kim; Hyunsook Lee

doi:10.1038/s41467-022-31156-z

Nature Communications (Jun 2022)

Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

Junyeop Lee,
Keewon Sung,
So Young Joo,
Jun-Hyeon Jeong,
Seong Keun Kim,
Hyunsook Lee

Affiliations

Junyeop Lee: Department of Biological Sciences & IMBG, Seoul National University
Keewon Sung: Department of Chemistry, Seoul National University
So Young Joo: Department of Biological Sciences & IMBG, Seoul National University
Jun-Hyeon Jeong: Department of Biological Sciences & IMBG, Seoul National University
Seong Keun Kim: Department of Chemistry, Seoul National University
Hyunsook Lee: Department of Biological Sciences & IMBG, Seoul National University

DOI: https://doi.org/10.1038/s41467-022-31156-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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G-quadruplex (G4) can be formed in telomeric DNA. Here the authors show that BRCA2 interacts with telomere G4 structure generated during telomere replication, protecting telomere from nuclease attack.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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