Large-scale association study for structural soundness and leg locomotion traits in the pig

Abstract

Abstract Background Identification and culling of replacement gilts with poor skeletal conformation and feet and leg (FL) unsoundness is an approach used to reduce sow culling and mortality rates in breeding stock. Few candidate genes related to soundness traits have been identified in the pig. Methods In this study, 2066 commercial females were scored for 17 traits describing body conformation and FL structure, and were used for association analyses. Genotyping of 121 SNPs derived from 95 genes was implemented using Sequenom's MassARRAY system. Results Based on the association results from single trait and principal components using mixed linear model analyses and false discovery rate testing, it was observed that APOE, BMP8, CALCR, COL1A2, COL9A1, DKFZ, FBN1 and VDBP were very highly significantly (P ALOX5, BMP8, CALCR, OPG, OXTR and WNT16 were very highly significantly (P APOE, CALCR, COL1A2, GNRHR, IHH, MTHFR and WNT16 were highly significantly (P CALCR and COL1A2 on SSC9 was detected, and haplotype -ACGACC- was highly significantly (P Conclusion The present findings provide a comprehensive list of candidate genes for further use in fine mapping and biological functional analyses.