Therapeutic Advances in Musculoskeletal Disease (Oct 2019)

Update on the safety and efficacy of teriparatide in the treatment of osteoporosis

  • Salvatore Minisola,
  • Cristiana Cipriani,
  • Giada Della Grotta,
  • Luciano Colangelo,
  • Marco Occhiuto,
  • Piergianni Biondi,
  • Chiara Sonato,
  • Evelina Vigna,
  • Mirella Cilli,
  • Jessica Pepe

DOI
https://doi.org/10.1177/1759720X19877994
Journal volume & issue
Vol. 11

Abstract

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Following the completion of the Fracture Prevention Trial, teriparatide was approved by the United States Food and Drug Administration and the European Medicine Agency as the first therapeutic anabolic agent for the treatment of postmenopausal women with severe osteoporosis. It subsequently received additional approval for the treatment of osteoporosis in men, and for the treatment of osteoporosis associated with glucocorticoid therapy in men and women at risk of fracture. In this review, we summarize the most important data concerning PTH 1-34 therapy before 2016 in the treatment of osteoporosis, and report some outstanding results published in the last 2 years. New data on safety will also discussed, together with the state of art of nonclassical utilization. Finally, in view of the recent approval of biosimilars, possible future landscapes are discussed.