The influence of genetic factors on the effectiveness, safety and tolerability of antiretroviral therapy in patients with hiv infection

V. G. Kanestri; V. I. Shakhgildyan; A. V. Kravchenko; D. S. Konnov; A. A. Popova

doi:10.22625/2072-6732-2021-13-1-21-28

Журнал инфектологии (Mar 2021)

The influence of genetic factors on the effectiveness, safety and tolerability of antiretroviral therapy in patients with hiv infection

V. G. Kanestri,
V. I. Shakhgildyan,
A. V. Kravchenko,
D. S. Konnov,
A. A. Popova

Affiliations

V. G. Kanestri: Central Research Institute of Epidemiology; University Clinic «H-Clinic»
V. I. Shakhgildyan: Central Research Institute of Epidemiology; University Clinic «H-Clinic»
A. V. Kravchenko: Central Research Institute of Epidemiology
D. S. Konnov: University Clinic «H-Clinic»; Peoples Friendship University of Russia
A. A. Popova: Central Research Institute of Epidemiology

DOI: https://doi.org/10.22625/2072-6732-2021-13-1-21-28
Journal volume & issue: Vol. 13, no. 1
pp. 21 – 28

Abstract

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This article provides an overview of the existing literature on the pharmacogenetic determinants of exposure and toxicity of antiretroviral drugs, as well as on genetic markers associated with the rate of disease progression. In addition, this article looks at current clinical opportunities as well as genetics in HIV drug development. Large-scale, integrated approaches to the genome are expected to significantly change the knowledge landscape in the future.

Published in Журнал инфектологии

ISSN: 2072-6732 (Print)
Publisher: Journal Infectology
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://journal.niidi.ru/

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Abstract

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