RMD Open (Apr 2024)
Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period
- ,
- Jesús Tornero,
- Alba Erra,
- Santos Castañeda,
- Carolina Pérez-García,
- Raimon Sanmartí,
- Sara Marsal,
- Ingrid Moller,
- Esperanza Naredo,
- Miguel A González-Gay,
- Celia Erausquin,
- Ivan Castellví,
- Javier Llorca,
- Alejandro Muñoz,
- María Galindo,
- Enrique Raya,
- Lydia Abasolo,
- Gema Bonilla,
- Alfonso Corrales,
- Inmaculada Ureña,
- Carlos Rodríguez-Lozano,
- Carlos González-Juanatey,
- Cristina Fernandez Carballido,
- Francisco J López-Longo,
- Miguel Ángel González-Gay,
- Eduardo Collantes,
- José A Miranda-Filloy,
- Sagrario Bustabad,
- Indalecio Monteagudo,
- Jose A Piqueras,
- Tatiana Cobo,
- Joan Maymó,
- Carmen Barbadillo,
- Soledad Ojeda,
- Jaime Calvo Alen,
- Antonio Fernandez Nebro,
- Isabel Rodríguez,
- Pilar Font,
- Martina Steiner,
- Eugenio Chamizo Carmona,
- Beatriz González Álvarez,
- Santiago Munoz,
- Joan M Nolla,
- Fernando Sánchez-Alonso,
- Julio Sanchez,
- Raul Menor Almagro,
- Ana Pérez Gómez,
- Monica Ibañez,
- Elena Heras-Recuero,
- Trinidad Pérez Sandoval,
- Miren Uriarte-Ecenarro,
- Angela Pecondón,
- Hye Sang Park,
- Jessica Polo y La Borda,
- Zulema Plaza,
- Carmen García Gómez,
- Ivan Ferraz-Amaro,
- Jesús Tomás Sanchez-Costa,
- Olga Carmen Sánchez-González,
- Ana Isabel Turrión-Nieves,
- Ana Perez-Alcalá,
- José L FernándezSueiro,
- José A Pinto-Tasende,
- Eugenia Gonzálezde Rábago,
- María J González-Fernández,
- Ramón Huguet Codina,
- Beatriz Yoldi,
- Mercedes Ramentol,
- Gabriela Ávila,
- Cayetano Alegre,
- Fernando Gamero,
- José García Torón,
- María P Moreno-Gil,
- Antonio Juan-Mas,
- Pilar Espiño,
- Inmaculada Ros,
- Horacio Berman,
- Oscar Fontseré Patón,
- Benjamín Fernández Gutiérrez,
- José M Pina-Salvador,
- María D Fábregas,
- Montserrat Romera,
- Jesús A García-Vadillo,
- Rosario García de Vicuña,
- María A Belmonte,
- María V Irigoyen,
- Olga Martínez González,
- Rebeca Belmonte Gómez,
- Pastora Granados Bautista,
- Azucena Hernández Sanz,
- José Santos Rey,
- Carmen O Sánchez-González,
- Javier Bachiller,
- Antonio Zea,
- Francisco J Manero,
- Chesús Beltrán Audera,
- Marta Medrano,
- Jesús Babío Herráez,
- Javier del Pino,
- Ruth López González,
- María Enriqueta Peiró,
- José M Senabre,
- José C Rosas,
- Isabel Rotés,
- Estefanía Moreno,
- Javier Calvo,
- Amalia Rueda,
- Pilar Morales,
- Ana Nieto,
- Ana Ruibal Escribano,
- Carmen García Gómez,
- Sergio Ros Expósito,
- Ginés Sánchez Nievas,
- Enrique Júdez Navarro,
- Manuela Sianes Fernández,
- Silvia Martínez Pardo,
- Manel Pujol,
- Alberto Cantabrana,
- Esmeralda Delgado,
- Sergio Rodríguez Montero,
- Javier Rivera Redondo,
- Teresa González Hernández,
- Francisco J González-Polo,
- José M Moreno,
- Emilio Giner Serret,
- Laura Cebrián Méndez,
- María Teresa Navío,
- Teresa Pedraz Penalva,
- Encarnación Pagán,
- Pablo Mesadel Castillo,
- Ana Cruz,
- Ana Turrión,
- Desireé Ruíz,
- Antonio López Meseguer,
- Manuel J Moreno,
- Luis F Linares,
- Mercedes Morcillo,
- María L González-Gómez,
- José M Aramburu,
- Natalia A Rivera,
- Olaia Fernández Berrizbeitia,
- Manel Riera,
- Yolanda María León,
- Miriam Amirall,
- Jordi Fiter,
- Julia Fernández Melón,
- Luis Espadaler,
- Joaquín Belzunegui,
- Inmaculada Bañegil,
- César Díaz,
- Ramón Valls,
- María Bonet,
- Eva Revuelta Evrard,
- Javier R Godo,
- José A González-Fernández
Affiliations
- Division of Surgery & Interventional Science, University College London, London, UK
- Jesús Tornero
- 4 Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain
- Alba Erra
- Rheumatology, Hospital Universitari Vall d`Hebron, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
- Santos Castañeda
- 14 Department of Rheumatology, Hospital Universitario La Princesa, Madrid, Spain
- Carolina Pérez-García
- 42 Rheumatology Department, Parc de Salut Mar Barcelona, Barcelona, Spain
- Raimon Sanmartí
- 2 Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
- Sara Marsal
- 1 Rheumatology Research Group, Vall d`Hebron Research Institute, Barcelona, Spain
- Ingrid Moller
- Human Anatomy and Embryology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences (Campus de Bellvitge), University of Barcelona, Barcelona, Spain
- Esperanza Naredo
- Department of Rheumatology and Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, IIS-FJD, Madrid, Spain
- Miguel A González-Gay
- Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain
- Celia Erausquin
- Department of Rheumatology, Hospital Doctor Negrin, Las Palmas GC, Spain
- Ivan Castellví
- Servicio de Reumatología, Hospital de Sant Pau, Barcelona, Spain
- Javier Llorca
- Universidad de Cantabria Facultad de Medicina, Santander, Cantabria, Spain
- Alejandro Muñoz
- Rheumatology Department, Hospital Universitario Virgen del Rocío Sevilla, Sevilla, Spain
- María Galindo
- 1 Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain
- Enrique Raya
- 22Servicio Andaluz de Salud, Complejo Hospitalario Universitario de Granada (Hospital Virgen de las Nieves), Granada, Spain
- Lydia Abasolo
- IdISSC and Rheumatology, Hospital Clinico Universitario San Carlos, Madrid, Spain
- Gema Bonilla
- Department of Rheumatology, La Paz University Hospital, Madrid, Spain
- Alfonso Corrales
- Reference hospitals, Rheumatology, Internal Medicine and Pathology Units, Spain, Spain
- Inmaculada Ureña
- UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain
- Carlos Rodríguez-Lozano
- Rheumatology Department, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas, Gran Canaria, Spain
- Carlos González-Juanatey
- Department of Rheumatology, Hospital Xeral-Calde, Lugo, Spain
- Cristina Fernandez Carballido
- Francisco J López-Longo
- 6Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
- Miguel Ángel González-Gay
- Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, University of Cantabria, Santander, Spain
- Eduardo Collantes
- Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), Córdoba, Spain
- José A Miranda-Filloy
- 2 Rheumatology Division, Hospital Xeral-Calde, Lugo, Spain
- Sagrario Bustabad
- Indalecio Monteagudo
- Rheumatology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain
- Jose A Piqueras
- Department of Health Psychology, Miguel Hernandez University of Elche, Elche, Spain
- Tatiana Cobo
- Rheumatology Service, Hospital La Paz, Madrid, Spain
- Joan Maymó
- Department of Rheumatology, IMAS, Hospital del Mar, Universidad Autónoma de Barcelona, Barcelona, Spain
- Carmen Barbadillo
- 5 Department of Rheumatology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain
- Soledad Ojeda
- 3Division of Interventional Cardiology, Reina Sofia Hospital, University of Córdoba, Maimonides Institute for Research in Biomedicine of Córdoba (IMIBIC), Córdoba, Spain
- Jaime Calvo Alen
- 10Hospital Universitario Araba
- Antonio Fernandez Nebro
- 8UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Spain
- Isabel Rodríguez
- 1Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Universitario Central de Asturias, Oviedo, Spain
- Pilar Font
- 1 Rheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC),Reina Sofia University Hospital, University of Córdoba, Cordoba, Spain
- Martina Steiner
- 1Bern University of Applied Sciences, Department of Health Professions, Discipline of Physiotherapy, Bern, Switzerland
- Eugenio Chamizo Carmona
- Beatriz González Álvarez
- Santiago Munoz
- Department of Rheumatology, Hospital Universitario Infanta Sofia, San Sebastian de los Reyes, Madrid, Spain
- Joan M Nolla
- Rheumatology Department, Hospital Universitari de Bellvitge, L`Hospitalet de Llobregat, Spain
- Fernando Sánchez-Alonso
- 3 Research Unit, Spanish Society of Rheumatology, Madrid, Spain
- Julio Sanchez
- Alivio Medical Center, Indianapolis, Indiana, USA
- Raul Menor Almagro
- 4Dept. of Rheumatology, Hospital Universitario de Jerez de la Frontera, Jerez de la Frontera, Spain
- Ana Pérez Gómez
- 22Rheumatology Dept., Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain
- Monica Ibañez
- 31Rheumatology Dept., Son Llàtzer University Hospital, Palma de Mallorca, Spain
- Elena Heras-Recuero
- 1Rheumatology Unit, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
- Trinidad Pérez Sandoval
- Miren Uriarte-Ecenarro
- Angela Pecondón
- Miguel Servet University Hospital, Zaragoza, Spain
- Hye Sang Park
- Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
- Jessica Polo y La Borda
- 1 Rheumatology, Hospital Universitario Rey Juan Carlos, Madrid, Spain
- Zulema Plaza
- 5 Research Unit, Spanish Society of Rheumatology, Madrid, Spain
- Carmen García Gómez
- 6 Rheumatology, Consorci Sanitari de Terrassa, Barcelona, Spain
- Ivan Ferraz-Amaro
- 7 Rheumatology Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
- Jesús Tomás Sanchez-Costa
- 9 Rheumatology, Research Unit, Spanish Society of Rheumatology, Madrid, Spain
- Olga Carmen Sánchez-González
- 10 Rheumatology, Hospital Universitario del Sureste, Madrid, Spain
- Ana Isabel Turrión-Nieves
- 11 Rheumatology Department, Hospital Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
- Ana Perez-Alcalá
- 12 Rheumatology, Hospital Universitario Príncipe Asturias, Alcalá de Henares, Madrid, Spain
- José L FernándezSueiro
- José A Pinto-Tasende
- Eugenia Gonzálezde Rábago
- María J González-Fernández
- Ramón Huguet Codina
- Beatriz Yoldi
- Mercedes Ramentol
- Gabriela Ávila
- Cayetano Alegre
- Fernando Gamero
- José García Torón
- María P Moreno-Gil
- Antonio Juan-Mas
- Pilar Espiño
- Inmaculada Ros
- Horacio Berman
- Oscar Fontseré Patón
- Benjamín Fernández Gutiérrez
- José M Pina-Salvador
- María D Fábregas
- Montserrat Romera
- Jesús A García-Vadillo
- Rosario García de Vicuña
- María A Belmonte
- María V Irigoyen
- Olga Martínez González
- Rebeca Belmonte Gómez
- Pastora Granados Bautista
- Azucena Hernández Sanz
- José Santos Rey
- Carmen O Sánchez-González
- Javier Bachiller
- Antonio Zea
- Francisco J Manero
- Chesús Beltrán Audera
- Marta Medrano
- Jesús Babío Herráez
- Javier del Pino
- Ruth López González
- María Enriqueta Peiró
- José M Senabre
- José C Rosas
- Isabel Rotés
- Estefanía Moreno
- Javier Calvo
- Amalia Rueda
- Pilar Morales
- Ana Nieto
- Ana Ruibal Escribano
- Carmen García Gómez
- Sergio Ros Expósito
- Ginés Sánchez Nievas
- Enrique Júdez Navarro
- Manuela Sianes Fernández
- Silvia Martínez Pardo
- Manel Pujol
- Alberto Cantabrana
- Esmeralda Delgado
- Sergio Rodríguez Montero
- Javier Rivera Redondo
- Teresa González Hernández
- Francisco J González-Polo
- José M Moreno
- Emilio Giner Serret
- Laura Cebrián Méndez
- María Teresa Navío
- Teresa Pedraz Penalva
- Encarnación Pagán
- Pablo Mesadel Castillo
- Ana Cruz
- Ana Turrión
- Desireé Ruíz
- Antonio López Meseguer
- Manuel J Moreno
- Luis F Linares
- Mercedes Morcillo
- María L González-Gómez
- José M Aramburu
- Natalia A Rivera
- Olaia Fernández Berrizbeitia
- Manel Riera
- Yolanda María León
- Miriam Amirall
- Jordi Fiter
- Julia Fernández Melón
- Luis Espadaler
- Joaquín Belzunegui
- Inmaculada Bañegil
- César Díaz
- Ramón Valls
- María Bonet
- Eva Revuelta Evrard
- Javier R Godo
- José A González-Fernández
- DOI
- https://doi.org/10.1136/rmdopen-2024-004207
- Journal volume & issue
-
Vol. 10,
no. 2
Abstract
Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients.Methods Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in RheuMAtology. Baseline data of 669 PsA patients with no history of CV events at the baseline visit, who were followed in rheumatology outpatient clinics at tertiary centres for 7.5 years, were retrospectively analysed to test the performance of the Systematic Coronary Risk Assessment (SCORE), the modified version (mSCORE) European Alliance of Rheumatology Associations (EULAR) 2015/2016, the SCORE2 algorithm (the updated and improved version of SCORE) and the QRESEARCH risk estimator version 3 (QRISK3).Results Over 4790 years of follow-up, there were 34 CV events, resulting in a linearised rate of 7.10 per 1000 person-years (95% CI 4.92 to 9.92). The four CV risk scales showed strong correlations and all showed significant associations with CV events (p<0.001). SCORE, mSCORE EULAR 2015/2016 and QRISK3 effectively differentiated between low and high CV risk patients, although the cumulative rate of CV events observed over 7.5 years was lower than expected based on the frequency predicted by these risk scales. Additionally, model improvement was observed when combining QRISK3 with any other scale, particularly the combination of QRISK3 and SCORE2, which yielded the lowest Akaike information criterion (411.15) and Bayesian information criterion (420.10), making it the best predictive model.Conclusions Risk chart algorithms are very useful for discriminating PsA at low and high CV risk. An integrated model featuring QRISK3 and SCORE2 yielded the optimal synergy of QRISK3’s discrimination ability and SCORE2’s calibration accuracy.